Friday 19 February 2021

Science, society & stereotypes: examining the lives of trailblazing women in STEM

I was recently flicking through a glossily illustrated Australian book on the history of STEM when I found the name of a pioneer I didn't recognise: Marjory Warren, a British surgeon who is best known today as the 'mother of modern geriatric medicine'. Looking in the index I could find only two other women scientists - compared to over one hundred and twenty men - in a book five hundred pages long! The other two examples were Marie Curie (of course) and American astronomer Vera Rubin. Considering that the book was published in 2008, I was astounded by how skewed this seemed to be. Granted that prior to the twentieth century, few women had the option of becoming involved in science and mathematics; but for any history of STEM, wouldn't the last century contain the largest proportion of subject material?

I therefore thought it would be interesting to choose case studies from the twentieth century to see what sort of obstacles - unique or otherwise - that women scientists faced until recently. If you ask most people to name a female scientist then Marie Curie would probably top the list, although a few countries might have national favourites: perhaps Rosalind Franklin in the UK or Rachel Carson in the USA, for example. Rather than choose the more obvious candidates such as these I have selected four women I knew only a little about, ordered by their date of birth.

Barbara McClintock (1902-1992) was an American cytogeneticist who was ahead of her time in terms of both research and social attitudes. Although her mother didn't want her to train as a scientist, she was lucky to have a father who thought differently to the accepted wisdom - which was that female scientists would be unable to find a husband! McClintock's abilities showed early in her training, leading to post-graduate fellowships which in turn generated cutting-edge research.

At the age of forty-two, Barbara McClintock was only the third woman to be elected to the US National Academy of Sciences. However, her rapid rise within the scientific establishment didn't necessarily assist her: such was the conservative nature of universities that women were not allowed to attend faculty meetings. 

After publishing her research to broad acceptance, McClintock's work then moved into what today would broadly come under the term of epigenetics. Several decades' ahead of its time, it was seen as too radical by most of her peers and so after facing intense opposition she temporarily stopped publishing her results. It is unlikely that being a woman was entirely responsible for the hostility to her work; similar resistance has frequently been experienced throughout the STEM avant-garde. It seems that only when other researchers found similar results to McClintock did the more hidebound sections of the discipline re-examine their negative attitude towards her work.

There has been a fair amount of discussion as to whether it was because McClintock was female, or because of her secretive personality (both at home as well as at work, for she never married) - or a combination of both - that delayed her receipt of the Nobel Prize in Physiology or Medicine. Even by the slow standards of that particular awards committee, 1983 was rather late in the day. However, by then she had already been the recipient of numerous other awards and prizes.

Regardless of the recognition it gave her, Barbara McClintock relished scientific research for the sake of uncovering nature's secrets. In that regard, she said: "I just have been so interested in what I was doing and it's been such a pleasure, such a deep pleasure, that I never thought of stopping...I've had a very, very, satisfying and interesting life."

Tikvah Alper (1909-1995) was a South African radiobiologist who worked on prions - otherwise known as 'misfolded' or 'rogue' proteins - and their relationship to certain diseases. Her outstanding abilities were recognised early, allowing her to study physics at the University of Cape Town. She then undertook post-graduate work in Berlin with the nuclear fission pioneer Lise Meitner, only to be forced to leave before completing her doctorate due to the rise in anti-Semitism in Germany.

Having had her research curtailed by her ethnicity, Alper was initially also stymied on her return to South Africa thanks to her private life: due to the misogynist rules of that nation's universities, married women were not allowed to remain on the faculty. Therefore, along with her husband the veterinary medicine researcher Max Sterne, she continued her work from home. However, eventually her talents were acknowledged and she was made head of the Biophysics section at the South African National Physics Laboratory in 1948. Then only three years later, Alper's personal life intervened once again; this time, she and her husband were forced to leave South Africa due to their opposition to apartheid.

After a period of unpaid research in London, Alper turned to studying the effects of radiation on different types of cells, rising to become head of the Medical Research Council Radiopathology Unit at Hammersmith Hospital. Alper's theories regarding prions were eventually accepted into the mainstream and even after retirement she continued working, writing a renowned text book, Cellular Radiobiology, in 1979. 

Alper's life suggests she was very much a problem solver, tackling anything that she felt needed progressing. As a result of this ethos she worked on a wide range of issues from the standing of women in science and society, to the injustice of apartheid, even to learning and teaching sign language after one of her son's was born profoundly deaf. Despite being forced to leave several nations for different reasons - not because she was a woman - Alper was someone who refused to concede defeat. In that respect she deserves much wider recognition today.

Dorothy Crowfoot Hodgkin (1910-1994) was interested in chemistry, in particular crystals, from a young age. Although women of her generation were encouraged in this area as a hobby, it was highly unusual for them to seek paid employment in the field. Luckily, her mother encouraged her interest and gave Hodgkin a book on x-ray crystallography for her sixteenth birthday, a gift which determined her career path. 

After gaining a first-class honours chemistry degree at Oxford, she moved to Cambridge for doctoral work under the x-ray crystallography pioneer J.D. Bernal. Not only did Hodgkin then manage to find a research post in her chosen field, working at both Cambridge and Oxford, she was able to pursue cutting edge work labelled as too difficult by her contemporaries, Hodgkin and her colleagues achieved ground-breaking results in critical areas, resolving the structure of penicillin, vitamin B12 and insulin. 

Hodgkin's gained international renown, appearing to have faced few of the difficulties experienced by her female contemporaries. In addition to having a well-equipped laboratory at Oxford, she was elected to the Royal Society in 1947 and became its Wolfson Research Professor in 1960. She was also awarded the Nobel Prize in Chemistry in 1964 - the only British woman to have been a recipient to date. Other prestigious awards followed, including the Royal Society's Copley Medal in 1976; again, no other woman has yet received that award.

Presumably in response to the loss of four maternal uncles in the First World War, Hodgkin was an active promoter of international peace. During the 1950s her views were deemed too left wing by the American government and she had to attain special permission to enter the United States to attend science conferences. Ironically, the Soviet Union honoured her on several occasions, admitting her as a foreign member of the Academy of Sciences and later awarding her the Lenin Peace Prize. She also communicated with her Chinese counterparts and became committed to nuclear disarmament, both through CND and Operation Pugwash.

Her work on insulin, itself of enormous importance, is just one facet of her life. Ironically, as someone associated with left-wing politics, she is often remembered today as being one of Margaret Thatcher's lecturers; despite their different socio-political leanings, they maintained a friendship into later life. All this was despite the increasing disability Hodgkin suffered from her mid-twenties due to chronic rheumatoid arthritis, which left her with seemingly minimal dexterity. Clearly, Dorothy Hodgkin was a dauntless fighter in her professional and personal life.

Marie Tharp (1920-2006) was an American geologist best known for her oceanographic cartography work regarding the floor of the Atlantic Ocean. Despite followed the advice of her father (a surveyor) and taking an undergraduate degree in humanities and music, Tharp also took a geology class; perhaps helping her father as a child boosted her interest in this subject. It enabled her to complete a master's degree in geology, thanks to the dearth of male students during the Second World War. Certainly, it was an unusual avenue for women to be interested in; at the time less than four percent of all earth sciences doctorates in the USA were awarded to women.

From a modern perspective, geology during the first half of the twentieth century appears to have been exceedingly hidebound and conservative. Tharp found she could not undertake field trips to uncover fossil fuel deposits, as women were only allowed to do office-based geological work - one explanation for this sexism being that having women on board ship brought bad luck! In fact, it wasn't until 1968 that Tharp eventually joined an expedition. 

However, thanks to painstaking study of her colleague Bruce Heezen's data, Tharp was able to delineate geophysical features such as the mid-Atlantic ridge and consider the processes that generated them. Her map of the Atlantic Ocean floor was far more sophisticated than anything that had previously been created, giving her insights denied to both her contemporaries as well as her predecessors. As such, Tharp suspected that the long-denigrated continental drift hypothesis, as envisaged by Alfred Wegener three decades previously, was correct. It was here that she initially came unstuck, with Heezen labelling her enthusiasm for continental drift as 'girl talk'. Let's hope that phrase wouldn't be used today!

In time though, yet more data (including the mirrored magnetic striping either side of the mid-Atlantic ridge) proved Tharp correct. Heezen's incredulity was replaced by acceptance, as continental drift was reformulated via seafloor spreading to become the theory of plate tectonics. Mainstream geology finally approved what Wegener had proposed, and Marie Tharp was a fundamental part of that paradigm shift. 

What is interesting is that despite receiving many awards in her later years, including the National Geographic Society's Hubbard Medal in 1978, her name is mentioned far less often than other pioneers of plate tectonics such as Harry Hess, Frederick Vine, Drummond Matthews, even Heezen. It's unclear if Tharp's comparative lack of recognition is due to her being female or because she was only one of many researchers working along similar lines. Her own comment from the era suggests that just being a women scientist was reason enough to dismiss her work: she noted that other professional's viewed her ideas with attitudes ranging "from amazement to skepticism to scorn."

There are countless other examples that would serve as case studies, including women from non-Western nations, but these four show the variety of experiences women scientists underwent during the twentieth century, ranging from a level of misogyny that would be unthinkable today to an early acceptance of the value of their work and a treatment not seemingly different from their male colleagues. I was surprised to find such a range of circumstances and attitudes, proving that few things are as straightforward as they are frequently portrayed. However, these examples do show that whatever culture they grow up in, the majority of the population consider its values to be perfectly normal; a little bit of thought - or hindsight - shows that just because something is the norm, doesn't necessarily mean it's any good. When it comes to the attitudes today, you only have to read the news to realise there's still some way to go before women in STEM are treated the same as their male counterparts.

Monday 25 January 2021

Ignorance is bliss: why admitting lack of knowledge could be good for science

"We just don't know" might be one of the best phrases in support of the scientific method ever written. But unfortunately it carries an inherent danger: if a STEM professional - or indeed an amateur scientist/citizen scientist - uses the term, it can be used by those wishing to disavow the subject under discussion. Even adding "- yet" to the end of it won't necessarily improve matters; we humans have an unfortunate tendency to rely on gut instinct rather than rational analysis for our world model, hence - well, just about any man-made problem you care to name, now or throughout history.

Even though trust in scientists and the real-world application of their work may have taken an upswing thanks to some rapid vaccine development during the current pandemic, there are many areas of scientifically-gleaned knowledge that are still as unpopular as ever. Incidentally, I wonder whether if it wasn't for much stricter laws in most countries today, we would have seen far more of the quackery that arose during the 1918 Spanish flu epidemic. During this period low-tech 'cures' included gas inhalation, enemas and blood-letting, the former about as safe as last year's suggestion to drink bleach. I've seen very little about alternative cures, no doubt involving crystals, holy water or good old-fashioned prayer, but then I probably don't mix in those sort of circles (and certainly don't have that type of online cookie profile). But while legislation might have prevented alternative pandemic treatments from being advertised as legitimate and effective, it hasn't helped other areas of science that suffer from widespread hostility. 

Partly this is due to the concept - at least in liberal democracies - of free speech and the idea that every thesis must surely have an antithesis worthy of discussion. Spherical planets not your bag, baby? Why not join the Flat Earth Society. It's easy to be glib about this sort of thing, but there are plenty of more serious examples of anti-scientific thinking that show no sign of abating. The key element that disparate groups opposing science seem to have in common is simple; it all comes down to where it disagrees with the world picture they learnt as a child. In most cases this can be reduced even further to just two words: religious doctrine.

This is where a humble approach to cutting-edge research comes in. Humility has rarely been a key characteristic of fictional scientists; Hollywood for example has often depicted (usually male) scientists as somewhere on a crude line between power-crazed megalomaniacs and naive, misguided innocents. The more sensational printed volumes and tv documentaries communicating scientific research to a popular audience likewise frequently eschew ambiguities or dead-ends in favour of this-is-how-it-is approach. Only, quite often, it isn't how it works at all. Doubts and negative results are not only a key element of science, they are a fundamental component; only by discarding failures can the search for an answer to an hypothesis (or if you prefer the description of the brilliant-yet-humble physicist Richard Feynman: a guess) be narrowed down. 

There are plenty of examples where even the most accomplished of scientists have admitted they don't know the answer to something in their area of expertise, such as Sir Isaac Newton being unable to resolve the ultimate cause of gravity. As it was, it took over two centuries for another genius - Albert Einstein - to figure it out. Despite all the research undertaken over the past century or so, the old adage remains as true as ever: good science creates as many new questions as it answers. Key issues today that are unlikely to gain resolution in the next few years - although never say never - include what is the nature of dark energy (and possibly likewise for dark/non-baryonic matter) and what is the ultimate theory behind quantum mechanics? 

Of course, these questions, fascinating though they are, hold little appeal to most people; they are just too esoteric and far removed from everyday existence to be bothered about. So what areas of scientific knowledge or research do non-scientists worry about? As mentioned above, usually it is something that involves faith. This can be broken down into several factors:

  1. Disagreement with a key religious text
  2. Implication that humans lack an non-corporeal element, such as an immortal soul
  3. Removal of mankind as a central component or focal point for the universe 

These obviously relate to some areas of science - from a layman's viewpoint - far more than others. Most non-specialists, even religious fundamentalists, don't appear to have an issue with atomic theory and the periodic table. Instead, cosmology and evolutionary biology are the disciplines likely to raise their ire. Both are not in any sense complete; the amount of questions still being asked is far greater than the answers so far gleaned from research. The former is yet to understand what 96% of the universe is composed of, while the latter is still piecing together the details of the origin and development of life of our planet, from primordial slime up to Donald Trump (so possibly more of a sideways move, then). 

Herein lies the issue: if scientists claim they are 'certain' about the cause of a particular phenomenon or feature of reality, but further research confirms a different theory, then non-scientists are  legitimately able to ask why the new idea is any more final than the previous one? In addition, the word 'theory' is also prone to misinterpretation, implying it is only an idea and not an hypothesis (guess, if you like) that hasn't yet failed any tests thrown at it, be they practical experiments, digital simulations or mathematical constructions. Bill Bryson's best-selling A Short History of Nearly Everything is an example of how science can be done a disservice by material meant to promote it, in that the book treats science as if it were an ever-expanding body of knowledge rather than as a collection of methods that are used to explore answerable questions about life, the universe, and of course, everything.

Perhaps one answer to all this would be for popular science journalism, from books written by professional scientists to short news items, to include elements related to what is not yet known. The simplistic approach that avoids the failures only serves to strengthen the opinion that experts are arrogant believers in their own personal doctrines, as inflexible and uncompromising as holy writ. 

Unfortunately, in efforts to be both concise and easy-to-comprehend, much science communication appears to render the discipline in this manner, avoiding dissension and doubt. In addition, the often wonderful - and yet to be resolved subtleties - of research are neglected. For example, the majority of specialists agree that birds are descended from theropod (i.e. carnivorous) dinosaurs, and yet the primary growth axis on the forelimbs of the two groups differs. This issue has not been satisfactorily answered, but the vast collection of evidence, both from fossils and experimentation, claims it as the most plausible solution to this particular phylogenetics tree. Further research, especially in embryology, may one day find a more complete solution.

Ultimately then, science education would probably benefit from it confirming boundaries of uncertainty, where they exist. This may help allay fears that the discipline wants to impose absolutes about everything; in most areas (the second law of thermodynamics excepted) we are still in the early stages of understanding. This doesn't mean that the Earth may be flat or only six thousand years old, but it does mean that science usually works in small steps, not giant paradigm shifts that offer the final say on an aspect of reality. After all, if scientists already knew everything about a subject, there wouldn't be any need for further research. What a boring world that would be!